2023/01/05 更新

写真a

キモリ ヨシタカ
木森 義隆
Yoshitaka Kimori

学位

  • 博士(情報工学)   課程 ( 2006年9月   九州工業大学 )

研究キーワード

  • セグメンテーション

  • パターン認識

  • 特徴抽出

  • 画像解析

研究分野

  • 情報通信 / 知能ロボティクス

  • 情報通信 / 知覚情報処理

  • ライフサイエンス / 医用システム

学歴

  • 九州工業大学   情報工学部   生命情報工学科   卒業

    1997年4月 - 2001年3月

  • 九州工業大学   大学院 情報工学研究科   情報科学専攻   博士前期課程   修了

    2001年4月 - 2003年3月

  • 九州工業大学   大学院 情報工学研究科   情報科学専攻   博士後期課程   単位取得満期退学

    2003年4月 - 2006年3月

経歴

  • 東京大学   医科学研究所   技術補佐員

    2006年4月 - 2006年9月

  • 東京大学   医科学研究所   産学官連携研究員

    2006年10月 - 2008年7月

  • 国立精神・神経医療センター   神経研究所   研究員

    2008年8月 - 2010年3月

  • (財)医療機器センター   流動研究員

    2008年8月 - 2010年3月

  • 自然科学研究機構 新分野創成センター   イメージングサイエンス研究分野   専門研究職員

    2010年4月 - 2011年9月

  • 自然科学研究機構 新分野創成センター   イメージングサイエンス研究分野   特任助教

    2011年10月 - 2018年3月

  • 自然科学研究機構 基礎生物学研究所   進化多様性生物学領域   特任助教 (兼任)

    2013年4月 - 2018年3月

  • 福井工業大学   環境情報学部   准教授

    2018年4月 - 2021年3月

  • 福井工業大学   環境情報学部   教授

    2021年4月 - 現在

▼全件表示

所属学協会

  • IEEE

  • 電子情報通信学会

 

論文

  • Pexophagy suppresses ROS-induced damage in leaf cells under high-intensity light 査読 国際誌

    Kazusato Oikawa, Shino Goto-Yamada, Yasuko Hayashi, Daisuke Takahashi, Yoshitaka Kimori, Michitaro Shibata, Kohki Yoshimoto, Atsushi Takemiya, Maki Kondo, Kazumi Hikino, Akira Kato, Keisuke Shimoda, Haruko Ueda, Matsuo Uemura, Keiji Numata, Yoshinori Ohsumi, Ikuko Hara-Nishimura, Shoji Mano, Kenji Yamada, Mikio Nishimura

    Nature Communications   13 ( 1 )   1 - 17   2022年12月

     詳細を見る

    Although light is essential for photosynthesis, it has the potential to elevate intracellular levels of reactive oxygen species (ROS). Since high ROS levels are cytotoxic, plants must alleviate such damage. However, the cellular mechanism underlying ROS-induced leaf damage alleviation in peroxisomes was not fully explored. Here, we show that autophagy plays a pivotal role in the selective removal of ROS-generating peroxisomes, which protects plants from oxidative damage during photosynthesis. We present evidence that autophagy-deficient mutants show light intensity-dependent leaf damage and excess aggregation of ROS-accumulating peroxisomes. The peroxisome aggregates are specifically engulfed by pre-autophagosomal structures and vacuolar membranes in both leaf cells and isolated vacuoles, but they are not degraded in mutants. ATG18a-GFP and GFP-2×FYVE, which bind to phosphatidylinositol 3-phosphate, preferentially target the peroxisomal membranes and pre-autophagosomal structures near peroxisomes in ROS-accumulating cells under high-intensity light. Our findings provide deeper insights into the plant stress response caused by light irradiation.

  • A Morphological Image Preprocessing Method Based on the Geometrical Shape of Lesions to Improve the Lesion Recognition Performance of Convolutional Neural Networks 査読 国際誌

    Yoshitaka Kimori

    IEEE Access   10   70919 - 70936   2022年6月

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    Convolutional neural networks (CNNs) play an important role in computer vision-related tasks for medical imaging. However, the quality of raw images in the dataset can be insufficient for the CNN model to learn the features of the target object. When the input image contains a complex background, the CNN model focuses on regions that are not essential for lesion recognition, such as background structures, leading to less accurate output prediction. This paper shows that this problem can be efficiently solved by an image preprocessing method based on mathematical morphology, which uses a priori knowledge about the lesion shape. The proposed method consists of h-dome transformation based on the geometrical shape information of the lesion region, and subsequent image histogram-modification processes, and has the ability to selectively enhance the lesion region from the background. This allows for the creation of images that explicitly represent the important region to be learned by the CNN model. Experiments on pulmonary nodule classification in chest x-ray images and skin lesion-region segmentation in dermatoscopic images demonstrate that the CNN models trained on the preprocessed dataset created by the proposed method achieve remarkable performance improvements compared to the CNN models trained on the original dataset.

  • Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement 査読

    Rei Nishimoto, Sandra Derouiche, Kei Eto, Aykut Deveci, Makiko Kashio, Yoshitaka Kimori, Yoshikazu Matsuoka, Hiroshi Morimatsu, Junichi Nabekura, Makoto Tominaga

    Proceedings of the National Academy of Sciences   118 ( 17 )   e201289411   2021年4月

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    Microglia maintain central nervous system homeostasis by monitoring changes in their environment (resting state) and by taking protective actions to equilibrate such changes (activated state). These surveillance and protective roles both require constant movement of microglia. Interestingly, induced hypothermia can reduce microglia migration caused by ischemia, suggesting that microglia movement can be modulated by temperature. Although several ion channels and transporters are known to support microglia movement, the precise molecular mechanism that regulates temperaturedependent movement of microglia remains unclear. Some members of the transient receptor potential (TRP) channel superfamily exhibit thermosensitivity and thus are strong candidates for mediation of this phenomenon. Here, we demonstrate that mouse microglia exhibit temperature-dependent movement in vitro and in vivo that is mediated by TRPV4 channels within the physiological range of body temperature. Our findings may provide a basis for future research into the potential clinical application of temperature regulation to preserve cell function via manipulation of ion channel activity.

  • Dynamic Capture-and-Release of Endoplasmic Reticulum Exit Sites by Golgi Stacks in Arabidopsis 査読

    Junpei Takagi, Yoshitaka Kimori, Tomoo Shimada, Ikuko Hara-Nishimura

    iScience   23 ( 7 )   101265   2020年7月

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    Protein transport from the endoplasmic reticulum (ER) to Golgi stacks is mediated by the coat protein complex COPII, which is assembled at an ER subdomain called ER exit site (ERES). However, the dynamic relationship between ERESs and Golgi stacks is unknown. Here, we propose a dynamic capture-and-release model of ERESs by Golgi stacks in Arabidopsis thaliana. Using variable-angle epifluorescence microscopy with high-temporal-resolution imaging, COPII-component-bound ERESs were detected as punctate structures with sizes of 300–500 nm. Some punctate ERESs are distributed on ER tubules and sheet rims, whereas others gather around a Golgi stack in an ER-network cavity to form a beaded-ring structure. Free ERESs that wander into an ER cavity are captured by a Golgi stack in a cytoskeleton-independent manner. Then, they are released by the Golgi stack for recycling. The dynamic ERES cycling might contribute to efficient transfer of de novo synthesized cargo proteins from the ER to Golgi stacks.

  • A morphological image processing method to improve the visibility of pulmonary nodules on chest radiographic images. 査読

    Yoshitaka Kimori

    Biomedical Signal Processing and Control   57   101744   2020年3月

     詳細を見る

    A pulmonary nodular shadow on a chest radiographic image is characteristic of lung cancer. However, nodular shadows often appear with very weak contrast. The target nodule shadow often overlaps with a shadow with strong contrast, such as that of the heart or rib; thus, it is difficult to emphasize the target region with ordinary contrast enhancement methods. In this article, a new pulmonary nodule enhancement method using a morphological subtraction method based on a modification of the h-dome transform is described. This method consists of two parts: a preprocessing step and nodule enhancement processing. The former reduces the uneven brightness of the background, and the latter emphasizes the nodule. With this method, the pulmonary nodule region is emphasized with the use of shape information of the nodule, whereas emphasis of the regions surrounding the nodule with different shapes is suppressed. This method also detects the boundary of the nodule as well as the edges of the surrounding anatomically normal structures. The performance of the proposed method has been verified by nodule enhancement experiments using synthetic and actual chest radiographic images from a public database. Furthermore, the efficiency of proposed method was tested by using contrast improvement index (CII), which is an index of improvement in contrast in the nodule region and its surroundings, and the results were quantitatively compared with those obtained from existing contrast emphasis methods. The proposed method has the highest value of CII, thereby confirming the effect of the contrast emphasis with this method.

  • Noninvasive measurement of cell/colony motion using image analysis methods to evaluate the proliferative capacity of oral keratinocytes as a tool for quality control in regenerative medicine. 査読

    Emi Hoshikawa, Taisuke Sato, Yoshitaka Kimori, Ayako Suzuki, Kenta Haga, Hiroko Kato, Koichi Tabeta, Daisuke Nanba, Kenji Izumi

    Journal of tissue engineering   10   2041731419881528   2019年10月

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    Image-based cell/colony analyses offer promising solutions to compensate for the lack of quality control (QC) tools for noninvasive monitoring of cultured cells, a regulatory challenge in regenerative medicine. Here, the feasibility of two image analysis algorithms, optical flow and normalised cross-correlation, to noninvasively measure cell/colony motion in human primary oral keratinocytes for screening the proliferative capacity of cells in the early phases of cell culture were examined. We applied our software to movies converted from 96 consecutive time-lapse phase-contrast images of an oral keratinocyte culture. After segmenting the growing colonies, two indices were calculated based on each algorithm. The correlation between each index of the colonies and their proliferative capacity was evaluated. The software was able to assess cell/colony motion noninvasively, and each index reflected the observed cell kinetics. A positive linear correlation was found between cell/colony motion and proliferative capacity, indicating that both algorithms are potential tools for QC.

  • A Method for Evaluating Three-Dimensional Morphological Features: A Case Study Using Marchantia polymorpha 査読

    Tomoyuki Furuya, Yoshitaka Kimori, Hirokazu Tsukaya

    Frontiers in plant science   10   1214   2019年10月

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    The description and evaluation of morphological features are essential to many biological studies. Bioimaging and quantification methods have been developed to analyze the morphological features of plants. However, efficient three-dimensional (3D) imaging and its quantification are still under development, particularly for studies of plant morphology, due to complex organ structure with great flexibility among individuals with the same genotype. In this study, we propose a new approach that combines a 3D imaging technique using micro-computed tomography and a mathematical image-processing method to describe 3D morphological features. As an example, we applied this method to Marchantia polymorpha, a new model plant used for the evolutional study of land plants, and we evaluated a mutant individual with an abnormal 3D shape. Using this new method, we quantitatively described the thallus morphology of M. polymorpha and distinguished the wild type from a mutant with different morphological features. Our newly established method can be applied to various tissues or bodies with irregular 3D morphology.

  • Autophagy controls reactive oxygen species homeostasis in guard cells that is essential for stomatal opening. 査読

    Shota Yamauchi, Shoji Mano, Kazusato Oikawa, Kazumi Hikino, Kosuke M Teshima, Yoshitaka Kimori, Mikio Nishimura, Ken-ichiro Shimazaki, Atsushi Takemiya

    Proceedings of the National Academy of Sciences   116 ( 38 )   19187 - 19192   2019年9月

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    Reactive oxygen species (ROS) function as key signaling molecules to inhibit stomatal opening and promote stomatal closure in response to diverse environmental stresses. However, how guard cells maintain basal intracellular ROS levels is not yet known. This study aimed to determine the role of autophagy in the maintenance of basal ROS levels in guard cells. We isolated the Arabidopsis autophagy-related 2 (atg2) mutant, which is impaired in stomatal opening in response to light and low CO2 concentrations. Disruption of other autophagy genes, including ATG5, ATG7, ATG10, and ATG12, also caused similar stomatal defects. The atg mutants constitutively accumulated high levels of ROS in guard cells, and antioxidants such as ascorbate and glutathione rescued ROS accumulation and stomatal opening. Furthermore, the atg mutations increased the number and aggregation of peroxisomes in guard cells, and these peroxisomes exhibited reduced activity of the ROS scavenger catalase and elevated hydrogen peroxide (H2O2) as visualized using the peroxisome-targeted H2O2 sensor HyPer. Moreover, such ROS accumulation decreased by the application of 2-hydroxy-3-butynoate, an inhibitor of peroxisomal H2O2-producing glycolate oxidase. Our results showed that autophagy controls guard cell ROS homeostasis by eliminating oxidized peroxisomes, thereby allowing stomatal opening.

  • Heterogeneous distribution of doublecortin‐expressing cells surrounding the rostral migratory stream in the juvenile mouse 査読

    Yuka Aoyagi, Terumasa Hibi, Yoshitaka Kimori, Masato Sawada, Ryosuke Kawakami, Kazunobu Sawamoto, Tomomi Nemoto

    Journal of Comparative Neurology   526 ( 16 )   2631 - 2646   2018年11月

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    In the postnatal mammalian brain, neural stem cells of the ventricular–subventricular zone continue to generate doublecortin (Dcx)-expressing immature neurons. Throughout life, these immature neurons migrate to the olfactory bulb through the rostral migratory stream (RMS). In this study, we investigated the distribution of these putative immature neurons using enhanced green fluorescent protein (EGFP) expression in the area surrounding the RMS of the juvenile Dcx-EGFP mice. Through the combined use of an optical clearing reagent (a 2,2′-thiodiethanol solution) and two-photon microscopy, we visualized three-dimensionally the EGFP-positive cells in the entire RMS and its surroundings. The resulting wide-field and high-definition images along with computational image processing methods developed in this study were used to comprehensively determine the position of the EGFP-positive cells. Our findings revealed that the EGFP-positive cells were heterogeneously distributed in the area surrounding the RMS. In addition, the orientation patterns of the leading process of these cells, which displayed the morphology of migrating immature neurons, differed depending on their location. These novel results provide highly precise morphological information for immature neurons and suggest that a portion of immature neurons may be detached from the RMS and migrate in various directions.

  • Endoplasmic Reticulum (ER) Membrane Proteins (LUNAPARKs) are Required for Proper Configuration of the Cortical ER Network in Plant Cells 査読

    Haruko Ueda, Natsumi Ohta, Yoshitaka Kimori, Teruka Uchida, Tomoo Shimada, Kentaro Tamura, Ikuko Hara-Nishimura

    Plant and Cell Physiology   59 ( 10 )   1931 - 1941   2018年10月

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    The endoplasmic reticulum (ER) is a large network made of membranous cisternae and tubules, which accounts for a large proportion of the total lipid bilayer endomembrane of the cell. In mammals and yeast, LUNAPARK proteins are preferentially localized at the three-way junctions of the ER network, stabilizing the junctions and establishing the ER architecture. We identified two Arabidopsis homologs and designated them LNPA and LNPB. Subcellular localization analysis with a non-dimerizable type of green fluorescent protein (GFP) revealed that both LNPA and LNPB are predominantly distributed throughout the ER, but not preferentially localized at the three-way junctions. Quantitative analysis of the network in the double mutant lnpa lnpb revealed that deficiency of LNPA and LNPB caused the cortical ER to develop poor ER cisternae and a less dense tubular network. These phenotypes are opposite to those of LNP-deficient mutants of yeast and mammals. Despite the importance of cysteine residues in the zinc finger motif of the yeast LNP homolog (Lnp1p), the corresponding cysteine residues of LNPA were not necessary for the stabilization of ER morphology because replacing the four cysteine residues in the zinc finger motif of the LNPA protein with alanine residues did not affect its function. A significant phenotype of lnpa lnpb is generation of large spherical structures from the ER. Formation of the structures might reduce the amounts of the ER membrane to be used for generating the network, resulting in poor development of the ER network. Taken together, our results suggest that plant LNPs function differently from those in yeast and mammals: they function to distribute ER membranes appropriately throughout the cells.

  • Length of myelin internodes of individual oligodendrocytes is controlled by microenvironment influenced by normal and input‐deprived axonal activities in sensory deprived mouse models 査読

    Yasuyuki Osanai, Takeshi Shimizu, Takuma Mori, Nobuhiko Hatanaka, Yoshitaka Kimori, Kenta Kobayashi, Shinsuke Koyama, Yumiko Yoshimura, Atsushi Nambu, Kazuhiro Ikenaka

    Glia   66 ( 11 )   2514 - 2525   2018年9月

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    本研究は,脳に分布するグリア細胞の一種である,オリゴデンドロサイト(稀突起グリア細胞)の髄鞘形成メカニズムを解明したものである.その機能を解明するためには,髄鞘構造に関する詳細な情報が必要であるが,顕微鏡を用いた観察では困難であった. 本研究では,蛍光顕微鏡像によって取得されたオリゴデンドロサイトの3Dデータに基づき,その髄鞘構造の可視化を実施し,機能発現機構の詳細を調べた.

  • ANGUSTIFOLIA contributes to the regulation of three-dimensional morphogenesis in the liverwort Marchantia polymorpha 査読

    Tomoyuki Furuya, Koro Hattori, Yoshitaka Kimori, Sakiko Ishida, Ryuichi Nishihama, Takayuki Kohchi, Hirokazu Tsukaya

    Development   145 ( 18 )   dev161398   2018年9月

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    ANGUSTIFOLIA(AN)遺伝子は,シロイヌナズナにおいて葉の細胞の横幅方向への極性伸長等の制御に関与しており,その欠損株では,葉の形態に関し,野生型とは異なるいくつかの特有な表現型をもつ.ゼニゴケのAN遺伝子は,シロイヌナズナ中でのANと同等の機能をもつことが知られているが,その役割の詳細は未知である.ゼニゴケのANホモログのノックアウト変異体は,葉状体がねじれる等の表現型を呈す.本研究では,ANホモログの形態形成に関与する役割について調べた.

  • Implications of maintenance of mother-bud neck size in diverse vital processes of Saccharomyces cerevisiae 査読

    Current Genetics   1 - 15   2018年7月

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    真核細胞のモデル系である出芽酵母では,ポストゲノム時代を迎えてフェノーム研究(表現型の網羅的研究)が盛んに行なわれるようになり,研究者の目に頼らない画像解析システムの開発の必要性が高まってきた.本手法では,大容量の画像中から酵母の領域を自動で検出し,母細胞から出芽する娘細胞の境界(bud neck)のサイズを定量的に記述する手法を開発し,そのサイズの維持が増殖等の細胞プロセスに重要であることを示した.

  • Different Activity Patterns in Retinal Ganglion Cells of TRPM1 and mGluR6 Knockout Mice 査読

    Haruki Takeuchi, Sho Horie, Satoru Moritoh, Hiroki Matsushima, Tesshu Hori, Yoshitaka Kimori, Katsunori Kitano, Yasuhiro Tsubo, Masao Tachibana, Chieko Koike

    BioMed Research International   2963232   2018年5月

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    感覚受容に関わるTRP(transient receptor potential)familyの1つであるTRPM1は網膜に強く発現しており,ヒトTRPM1遺伝子の変異が完全型停止性夜盲症の原因になっていることが知られている.また,TRPM1は,網膜ON型双極細胞の樹状突起において,mGluR
    6(代謝型グルタミン酸受容体6)と共局在することが分かっている.本研究では,TRMP1とmGluR6ノックアウト(KO)マウスの網膜桿体ON型双極細胞の神経終末の構造解析を行い,TRMP1 KO網膜では,mGluR KO網膜よりもシナプス終末のサイズは有意に小さいことを見出した.このことは,桿体ON型双極細胞においては,mGluR6ではなく,TRMP1の欠損がシナプス終末の制術に影響を及ぼしていることを示唆している.

  • YTH-RNA-binding protein prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci 査読

    Yuichi Shichino, Yoko Otsubo, Yoshitaka Kimori, Masayuki Yamamoto, Akira Yamashita

    eLife   7   e32155   2018年2月

  • Rabies Virus‐Mediated Oligodendrocyte Labeling Reveals A Single Oligodendrocyte Myelinates Axons from Distinct Brain Regions 査読

    Yasuyuki Osanai, Takeshi Shimizu, Takuma Mori, Yumiko Yoshimura, Nobuhiko Hatanaka, Atsushi Nambu, Yoshitaka Kimori, Shinsuke Koyama, Kenta Kobayashi, Kazuhiro Ikenaka

    Glia   65   93 - 105   2017年1月

  • Ultrastructure of Compacted DNA in Cyanobacteria by High-Voltage Cryo-Electron Tomography 査読

    Kazuyoshi Murata, Sayuri Hagiwara, Yoshitaka Kimori, Yasuko Kaneko

    Scientific Reports   6   34934   2016年10月

  • Quantifying Morphological Features of Actin Cytoskeletal Filaments in Plant Cells Based on Mathematical Morphology 査読

    Yoshitaka Kimori, Kazumi Hikino, Mikio Nishimura, Shoji Mano

    Journal of Theoretical Biology   389   123 - 131   2016年1月

  • Irradiation-injured Brain Tissues Can Self-Renew in The Absence of The Pivotal Tumor Suppressor p53 in The Medaka (Oryzias latipes) Embryo 査読

    Takako Yasuda, Yoshitaka Kimori, Kento Nagata, Kento Igarashi, Tomomi Watanabe-Asaka, Shoji Oda, Hiroshi Mitani

    Journal of Radiation Research   57   9 - 15   2016年1月

  • Single-Cell Phenomics in Budding Yeast 査読

    Yoshikazu Ohya, Yoshitaka Kimori, Hiroki Okada, Shinsuke Ohnuki

    Molecular Biology of the Cell   26   3920 - 3925   2015年11月

  • 形状解析のための画像処理:mathematical morphologyに基づく画像コンポーネントの抽出 査読

    木森義隆

    Cytometry Research   24   15 - 20   2014年10月

  • Morphological Image Processing for Quantitative Shape Analysis of Biomedical Structures: Effective Contrast Enhancement 査読

    Yoshitaka Kimori

    Journal of Synchrotron Radiation   20   848 - 853   2013年11月

  • Novel Configuration of A Myosin II Transient Intermediate Analogue Revealed by Quick-Freeze Deep-Etch Replica Electron Microscopy 査読

    Yoshitaka KIMORI, Norio BABA, Eisaku KATAYAMA

    Biochemical Journal   450   23 - 35   2013年2月

  • Gamma-ray irradiation promotes premature meiosis of spontaneously differentiating testis-ova in the testis of p53 deficient medaka (Oryzias latipes) 査読

    T Yasuda, S Oda, Z Li, Y Kimori, Y Kamei, T Ishikawa, T Todo, H Mitani

    Cell Death and Disease   3   e395   2012年10月

  • Mathematical Morphology-based Approach to the Enhancement of Morphological Features in Medical Images 査読

    Yoshitaka Kimori

    Journal of Clinical Bioinformatics   1   33   2011年12月

  • Myostatin-deficient medaka Exhibit a Double-muscling Phenotype with Hyperplasia and Hypertrophy, which Occur Sequentially During Post-hatch Development 査読

    Shin-ichi Chisada, Hiroyuki Okamoto, Yoshihito Taniguchi, Yoshitaka Kimori, Atsushi Toyoda, Yoshiyuki Sakaki, Shunichi Takeda, Yasutoshi Yoshiura

    Developmental Biology   359   82 - 94   2011年11月

  • Fractal Dimension Analysis and Mathematical Morphology of Structural Changes in Actin Filaments Imaged by Electron Microscopy 査読

    Yoshitaka Kimori, Eisaku Katayama, Nobuhiro Morone, Takao Kodama

    Journal of Structural Biology   176   1 - 8   2011年10月

  • Extended Morphological Processing: A Practical Method for Automatic Spot Detection of Biological Markers from Microscopic Images 査読

    Yoshitaka Kimori, Norio Baba, Nobuhiro Morone

    BMC Bioinformatics   11   373   2010年7月

  • Procedure to Analyze Surface Profiles of the Protein Molecules Visualized by Quick-Freeze Deep-Etch Replica Electron Microscopy 査読

    Yoshitaka Kimori, Yosuke Oguchi, Norihiko Ichise, Norio Baba, Eisaku Katayama

    Ultramicroscopy   107   25 - 39   2007年1月

  • Aggregation of Partially Unfolded Myosin Subfragment-1 into Spherical Oligomers with Amyloid-Like Dye-Binding Properties 査読

    Hideyuki Komatsu, Nami Shinotani, Yoshitaka Kimori, Jun-ichiro Tokuoka, Kuniyoshi Kaseda, Hiroyuki Nakagawa, Takao Kodama

    Journal of Biochemistry   139   989 - 996   2006年6月

▼全件表示

書籍等出版物

  • 非線形画像・信号処理 (モルフォロジの基礎と応用)

    浅野晃,浅野(村木)千恵,木森義隆,棟安実治,延原肇,藤尾光彦( 担当: 共著 ,  範囲: 第4章2節「バイオイメージングへの応用」,pp. 87-94,第5章2節「ライブセルイメージング」,pp. 123-126.)

    丸善株式会社  2010年10月 

  • Using image-based resources: databases for plant organelle dynamics, and applications based on image information, In Introduction to Sequence and Genome Analysis I

    Mano S., Kimori Y., Takeda T., Miwa T., Nishikawa S., Mimura T.( 担当: 共著 ,  範囲: 第3章「Morphological Image Processing for the Quantitative Analysis of Biological Images」, pp. 90-99.)

    iConcept Press  2013年7月 

MISC

  • 人間の視覚処理を模した新たな顕微鏡画像処理法

    木森義隆,片山栄作

    生物物理   48   125 - 130   2008年3月

  • Mathematical Morphologyに基づくバイオイメージからの構造情報の抽出と解析

    木森義隆,諸根信弘,片山栄作

    顕微鏡   44   41 - 46   2009年5月

  • 出芽酵母で拡がる細胞の画像解析研究

    大矢禎一,木森義隆

    映像情報メディア学会誌   67   765 - 770   2013年9月

  • 「定量化」時代の生物画像処理

    木森義隆

    顕微鏡   50   54 - 60   2015年4月

講演・口頭発表等

  • 深層学習を用いた画像認識:結果の解釈と認識精度向上のための画像処理技術 招待

    木森義隆

    ABiS Symposium イメージングデータ解析が拓く生命科学の新時代  2022年3月  新学術領域研究『学術研究支援基盤形成』先端バイオイメージング支援プラットフォーム(ABiS)

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    近年、畳み込みニューラルネットワークをはじめとした、深層学習に基づく画像認識技術は、コンピュータビジョンの分野で重要な役割を果たしている。顕微鏡画像の分類や特定領域のセグメンテーションなど、バイオイメージングの分野においてもその技術は多用されてきた。このため、推論結果に対し、判断根拠の説明性がより重要視されるようになった。また、学習データに含まれる、ノイズや輝度バイアス、さらには背景構造などの存在が、推論結果の精度に影響を及ぼすことも知られてきた。本講演では、画像認識結果を解釈するうえで重要となる説明可能なAI(Explainable AI, XAI)技術について概説するとともに、ネットワークの認識精度や汎化性を向上させるための画像処理技術について、具体的な研究事例を交えて説明したい。

  • 生物医学画像の情報処理,AI技術の展望

    木森義隆

    文部科学省 新学術領域研究 2018年度市民公開シンポジウム AIが変える医学の未来 (ミライ) -人工知能と診断の交差点-  文部科学省新学術領域研究 学術研究支援基盤形成 生命科学連携推進協議会

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    本シンポジウムは,「人工知能(AI)による医療診断の可能性」をテーマとし,医療の現場で実際に利活用されているAI技術について議論するものであった.
    「生物医学画像の情報処理,AI技術の展望」という演題で講演を行った.情報工学研究の立場から,医療診断の基礎となる理論や技術,さらにその問題点や応用に関する今後の展望について講演を行った.その後,他の講演者らと共に,パネルディスカッションも実施し,市民から寄せられた質問に回答するとともに,AI技術に関する諸問題等について討議を行った.

  • 生物顕微鏡画像における形態情報の抽出とその数量的表現

    木森義隆

    日本植物学会第82回大会  日本植物学会

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    本講演では,生物画像の特性を考慮し,その処理に特化した画像情報解析手法である,数理形態学に基づいた画像処理手法について概説し,応用事例を紹介した.そして,それを踏まえたうえで,より一般的な観点から形態情報の抽出および数量化に関する今後の課題を明確にし,それを解決するための画像情報解析技術の発展性について議論した.

  • Quantitative measurement of mobility of cell colony using image analysis methods for quality control of oral keratinocytes: A preliminary study 国際会議

    5th Tissue Engineering and Regenerative Medicine International Society World Congress 

  • 数理形態学を用いたバイオイメージ・インフォ マティクス

    木森義隆

    日本オペレーションズ・リサーチ学会「数理的発想とその実践」 第1回研究集会  日本オペレーションズ・リサーチ学会

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    近年,生物医学画像を対象とし,情報学的なアプローチにより,生命現象に関する諸問題を解こうとする学術分野,「バイオイメージ・インフォマティクス」が進展し,様々な画像処理技術が誕生している.本講演では,数理形態学を用いた研究事例を報告するとともに,数理最適化技術の適用可能性についても議論した.

 

担当経験のある授業科目

  • 画像情報処理論

    機関名:福井工業大学

  • プログラミング実習Ⅲ (C++言語)

    機関名:福井工業大学

  • プログラミング実習Ⅳ (C++言語)

    機関名:福井工業大学

  • コンピュータアーキテクチャ

    機関名:福井工業大学

  • 情報社会特論 (大学院)

    機関名:福井工業大学

  • 情報工学特論 (大学院)

    機関名:福井工業大学

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